If you leave school with the basic office skills you should get an entry level secretary job. Employers will expect MS Office skills for even the most basic positions.
Typing and general communication skills are important for secretarial careers. Because secretaries are often client facing, some experience working with customers may also stand you in good stead. The ability to work independently is important.
Retraining is an integral part of secretarial jobs because of increasing levels of office automation. There is a demand for secretaries who are adaptable and versatile.